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A Lisch nodule is a pigmented hamartomatous nodular aggregate of dendritic melanocytes affecting the iris,〔(【引用サイトリンク】chapter=151 )〕 named after Austrian ophthalmologist Karl Lisch (1907–1999), who first recognized them in 1937. The first published use of the term, "Lisch nodule," was in the New England Journal of Medicine "Medical Progress" series article of December 31, 1981 (Riccardi VM: Von Recklinghausen Neurofibromatosis. N Engl J Med 1981;305:1617-27). These nodules are found in neurofibromatosis type 1, and are present in greater than 94% of patients over the age of six.〔 They are clear, yellow-brown, oval to round, dome-shaped papules that project from the surface of the iris. These nodules typically do not affect vision, but are very useful in diagnosis.〔 They are detected by slit lamp examination.〔 Immunohistochemistry stains positive against vimentin and S-100, and points to an ectodermal origin.〔 Their precise origin and structure, however, is still under debate.〔 They are not found in neurofibromatosis type 2. == See also == * Glaucoma * Watson syndrome 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Lisch nodule」の詳細全文を読む スポンサード リンク
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